Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29612271 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL3213459 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL7194701 | 0.88 | BRD4 (0.31) | BRD4CREBBP | |
| Hydrochloric Acid SCHEMBL2524020 | 0.88 | KIF11 (0.34) | KIF11RAB9ASMN1; SMN2PARP1 | |
| Hydrochloric Acid SCHEMBL29612290 | 0.88 | KIF11 (0.34) | KIF11RAB9ASMN1; SMN2PARP1 | |
| Hydrochloric Acid SCHEMBL29612298 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL29612272 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL15303089 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL4470406 | 0.87 | BRD4 (0.33) | KIF11BRD4CREBBPDGAT1 | |
| Hydrochloric Acid SCHEMBL29612286 | 0.85 | SYK (0.33) | NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033975-B1 | Catalyst composition | BASELL POLYOLEFINE GMBH (DE) | 2014-05-14 | — | — | EP | disclosed |
| US-8039569-B2 | Polyethylene molding compositions for injection molding applications | BASELL POLYOLEFINE GMBH (DE) | 2011-10-18 | — | — | US | disclosed |
| EP-1874830-B1 | MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST | BASELL POLYOLEFINE GMBH (DE) | 2010-10-20 | — | — | EP | disclosed |
| US-20090311453-A1 | Molding compostion comprsing polyethlene for preparing films and process for preparing the molding composition in the presence of a mixed catalyst | BASELL POLYOLEFINE GMBH (DE) | 2009-12-17 | — | — | US | disclosed |
| US-20090306324-A1 | Polyethylene molding compositions for injection molding applications | BASELL POLYOLEFINE GMBH (DE) | 2009-12-10 | — | — | US | disclosed |
| EP-2033975-A1 | Catalyst composition | Basell Polyolefine GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| EP-1874831-B1 | POLYETHYLENE MOLDING COMPOSITIONS FOR INJECTION MOLDING APPLICATIONS | BASELL POLYOLEFINE GMBH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1874830-A1 | MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST | Basell Polyolefine GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114209-A1 | MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST | BASELL POLYOLEFINE GMBH (DE) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311453-A1 | Molding compostion comprsing polyethlene for preparing films and process for preparing the molding composition in the presence of a mixed catalyst | MAFG, PARG, MICOS13 | KIF11 1218/4885BRD4 4832/4885CREBBP 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.