⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29617535 | 0.82 | LMNA (0.45) | — | |
| SCHEMBL3316886 | 0.82 | LMNA (0.45) | — | |
| SCHEMBL21748209 | 0.81 | — | — | |
| SCHEMBL7526154 | 0.69 | LMNA (0.42) | — | |
| SCHEMBL456619 | 0.69 | — | — | |
| SCHEMBL3765003 | 0.65 | LMNA (0.40) | — | |
| SCHEMBL3145985 | 0.65 | — | — | |
| SCHEMBL3948377 | 0.65 | — | — | |
| SCHEMBL844660 | 0.65 | — | — | |
| SCHEMBL3549870 | 0.63 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066344-A1 | BENZOTHIAZOLE, BENZOISOXAZOLE, AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2025-02-27 | — | — | US | disclosed |
| EP-4448500-A1 | BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118401502-A | Benzothiazole, benzisoxazole and benzodioxole analogs as RXFP1 receptor agonists | 百时美施贵宝公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2023114822-A1 | BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |