Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243633 | 0.82 | TYK2 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25246327 | 0.82 | TYK2 (0.52) | — | |
| SCHEMBL25241385 | 0.80 | TTK (0.42) | TTK | |
| SCHEMBL25242828 | 0.80 | LRRK2 (0.47) | LRRK2TTK | |
| SCHEMBL25239490 | 0.79 | LRRK2 (0.52) | LRRK2TTK | |
| SCHEMBL25286881 | 0.78 | TTK (0.57) | LRRK2TTK | |
| SCHEMBL25287907 | 0.78 | TTK (0.42) | TTK | |
| SCHEMBL25289693 | 0.78 | S1PR1 (0.39) | TTK | |
| SCHEMBL25283961 | 0.76 | EGFR (0.48) | TTK | |
| SCHEMBL25284382 | 0.75 | HPGD (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |