Sugi Predict

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SCHEMBL2524696

SCHEMBL2524696

CC(=O)NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1F

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 2/20 0.34
▸ CA1 P00915 2/20 0.34
▸ CA2 P00918 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ IKBKB O14920 2/20 0.33
▸ CHUK O15111 2/20 0.33
▸ F10 P00742 1/20 0.33
▸ PTGS2 P35354 1/20 0.32
▸ SETDB1 Q15047 1/20 0.31
▸ RIPK1 Q13546 1/20 0.31
▸ CNR1 P21554 1/20 0.31
▸ BDKRB1 P46663 1/20 0.31
▸ EPHX2 P34913 1/20 0.31
▸ NR1H4 Q96RI1 1/20 0.31
▸ TRPA1 O75762 1/20 0.31
▸ FFAR1 O14842 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ PDK2 Q15119 1/20 0.31
▸ MALT1 Q9UDY8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2523120 0.94 MTOR (0.34) MTORCA1CA2POLBIKBKB
SCHEMBL2524229 0.93 F10 (0.35) CA1CA2POLBF10PTGS2
SCHEMBL14685964 0.92 FFAR1 (0.33) CA1CA2RIPK1CNR1FFAR1
SCHEMBL2520672 0.91 CNR1 (0.34) CA1CA2POLBCNR1
SCHEMBL2518676 0.91 LMNA (0.37) MTOR
SCHEMBL2521287 0.90 F10 (0.34) CA1CA2POLBF10PTGS2
SCHEMBL2524704 0.90 CNR1 (0.35) CA1CA2F10CNR1EPHX2
SCHEMBL2523771 0.89 CNR1 (0.34) CA1CA2CNR1FFAR1
SCHEMBL2523124 0.89 MTOR (0.38) MTORCA1CA2CNR1
SCHEMBL2553060 0.89 PDE3B (0.35) CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2556060-A1 SUBSTITUTED 3,5- DIPHENYL-ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES AH USA 42 LLC (US) 2013-02-13 — — EP claimed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO claimed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US claimed
EP-2556060-A1 SUBSTITUTED 3,5- DIPHENYL-ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES AH USA 42 LLC (US) 2013-02-13 — — EP disclosed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO disclosed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO disclosed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US disclosed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US disclosed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES CYP4X1, COL1A1, RDX MTOR 3940/4885CA1 2771/4885CA2 1675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.