Sugi Predict

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SCHEMBL2524704

SCHEMBL2524704

CCNC(=O)CC(=O)NCc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1F

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 3/20 0.35
▸ CA1 P00915 2/20 0.32
▸ CA2 P00918 2/20 0.32
▸ P2RX7 Q99572 7/20 0.32
▸ ERCC1 P07992 1/20 0.32
▸ ERCC4 Q92889 1/20 0.32
▸ EPHX2 P34913 1/20 0.31
▸ NR1H4 Q96RI1 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ F10 P00742 1/20 0.31
▸ TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2520672 0.93 CNR1 (0.34) CNR1CA1CA2P2RX7ERCC1
SCHEMBL2523771 0.91 CNR1 (0.34) CNR1CA1CA2P2RX7ERCC1
SCHEMBL2521281 0.90 P2RX7 (0.32) CNR1CA1CA2P2RX7F10
SCHEMBL2524696 0.90 MTOR (0.34) CNR1CA1CA2EPHX2NR1H4
SCHEMBL2519289 0.89 CNR1 (0.33) CNR1ERCC1ERCC4ALDH1A1LMNA
SCHEMBL2523124 0.89 MTOR (0.38) CNR1CA1CA2P2RX7ERCC1
SCHEMBL14685964 0.89 FFAR1 (0.33) CNR1CA1CA2P2RX7ALDH1A1
SCHEMBL2518676 0.88 LMNA (0.37) LMNATRPV1
SCHEMBL2521270 0.87 RAB9A (0.36) CNR1P2RX7ERCC1ERCC4ALDH1A1
SCHEMBL12206626 0.87 CNR1 (0.36) CNR1CA1CA2P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2556060-A1 SUBSTITUTED 3,5- DIPHENYL-ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES AH USA 42 LLC (US) 2013-02-13 — — EP claimed
CN-102933563-A Substituted 3,5-di phenyl-isoxazoline derivatives as insecticides and acaricides AH US 42 CO LTD 2013-02-13 — — CN claimed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO claimed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US claimed
EP-2556060-A1 SUBSTITUTED 3,5- DIPHENYL-ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES AH USA 42 LLC (US) 2013-02-13 — — EP disclosed
CN-102933563-A Substituted 3,5-di phenyl-isoxazoline derivatives as insecticides and acaricides AH US 42 CO LTD 2013-02-13 — — CN disclosed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO disclosed
WO-2011124998-A1 SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES PFIZER INC. (US) 2011-10-13 — — WO disclosed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US disclosed
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES PFIZER INC. (US) 2011-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110251247-A1 SUBSTITUTED ISOXAZOLINE DERIVATIVES CYP4X1, COL1A1, RDX CNR1 1898/4885CA1 2771/4885CA2 1675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.