Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25254831 | 0.95 | LMNA (0.44) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL25249262 | 0.94 | LMNA (0.43) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL7185154 | 0.81 | KMT2A (0.54) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL25290064 | 0.80 | MAPT (0.50) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL25247464 | 0.79 | KMT2A (0.49) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL25291696 | 0.79 | KMT2A (0.49) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL24716109 | 0.78 | MEN1 (0.39) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL24715779 | 0.77 | PDE4B (0.36) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL25259070 | 0.75 | KMT2A (0.46) | LMNAMEN1KMT2AMAPTTDP1 | |
| SCHEMBL25248042 | 0.75 | MEN1 (0.46) | LMNAMEN1KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503440-B2 | Nitroxoline derivative, preparation method therefor, and use thereof | Jiangsu Yahong Meditech Co. (CN) | 2025-12-23 | — | — | US | disclosed |
| US-20230295094-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20230295094-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20230295094-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| EP-4194441-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |
| EP-4194441-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |
| CN-115867540-A | Nitroxoline derivatives, preparation method and application thereof | 江苏亚虹医药科技股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022028321-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2022-02-10 | — | — | WO | disclosed |
| CN-111960998-A | Nitroxoline derivatives, preparation method and application thereof | 江苏亚虹医药科技有限公司 | 2020-11-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12503440-B2 | Nitroxoline derivative, preparation method therefor, and use thereof | NOS1, NQO1, NOS2 | LMNA 3149/4885MEN1 569/4885KMT2A 3512/4885 |
| US-20230295094-A1 | NITROXOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | NOS1, NQO1, NOS2 | LMNA 3149/4885MEN1 569/4885KMT2A 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.