SCHEMBL2525155

SCHEMBL2525155

CC1=Cc2c(-c3cc(C)cc(C)c3)cccc2C1[Zr](Cl)(Cl)C1C(C)=Cc2c(-c3cc(C)cc(C)c3)cccc21

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.31
CREBBP Q92793 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5952170 0.87 EDNRB (0.32)
SCHEMBL2525984 0.85 PDCD1 (0.33) BRD4
SCHEMBL5837337 0.84
Hydrochloric Acid SCHEMBL31386845 0.84 PDCD1 (0.33) BRD4
SCHEMBL7943368 0.84 PDCD1 (0.33) BRD4
SCHEMBL28326607 0.83 RXRB (0.31)
SCHEMBL29216495 0.83
SCHEMBL20496069 0.81 PDCD1 (0.31)
SCHEMBL6553568 0.81 PDCD1 (0.31)
SCHEMBL5952835 0.81 GSTP1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2033975-B1 Catalyst composition BASELL POLYOLEFINE GMBH (DE) 2014-05-14 EP disclosed
US-8039569-B2 Polyethylene molding compositions for injection molding applications BASELL POLYOLEFINE GMBH (DE) 2011-10-18 US disclosed
EP-1874830-B1 MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST BASELL POLYOLEFINE GMBH (DE) 2010-10-20 EP disclosed
US-20090311453-A1 Molding compostion comprsing polyethlene for preparing films and process for preparing the molding composition in the presence of a mixed catalyst BASELL POLYOLEFINE GMBH (DE) 2009-12-17 US disclosed
US-20090306324-A1 Polyethylene molding compositions for injection molding applications BASELL POLYOLEFINE GMBH (DE) 2009-12-10 US disclosed
EP-2033975-A1 Catalyst composition Basell Polyolefine GmbH (DE) 2009-03-11 EP disclosed
EP-1874831-B1 POLYETHYLENE MOLDING COMPOSITIONS FOR INJECTION MOLDING APPLICATIONS BASELL POLYOLEFINE GMBH (DE) 2008-12-03 EP disclosed
EP-1874830-A1 MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST Basell Polyolefine GmbH (DE) 2008-01-09 EP disclosed
EP-1778779-A1 STRETCH BLOW-MOLDED CONTAINERS FROM METALLOCENE PROPYLENE POLYMER COMPOSITIONS Basell Poliolefine Italia S.r.l. (IT) 2007-05-02 EP disclosed
WO-2006114209-A1 MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST BASELL POLYOLEFINE GMBH (DE) 2006-11-02 WO disclosed
US-7038070-B2 Preparation of preparing substituted indanones BASELL POLYOLEFINE GMBH (DE) 2006-05-02 US disclosed
WO-2006018812-A1 STRETCH BLOW-MOLDED CONTAINERS FROM METALLOCENE PROPYLENE POLYMER COMPOSITIONS BASELL POLIOLEFINE ITALIA S.R.L. (US) 2006-02-23 WO disclosed
US-6963017-B2 Preparation of preparing substituted indanones BASELL POLYOLEFINE GMBH (DE) 2005-11-08 US disclosed
EP-0968158-B1 METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM BASELL POLYOLEFINE GMBH (DE) 2005-08-10 EP disclosed
US-20050033076-A1 Preparation of preparing substituted indanones EQUISTAR CHEMICALS, LP 2005-02-10 US disclosed
US-20030009046-A1 Preparation of preparing substituted indanones EQUISTAR CHEMICALS, LP 2003-01-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090311453-A1 Molding compostion comprsing polyethlene for preparing films and process for preparing the molding composition in the presence of a mixed catalyst MAFG, PARG, MICOS13 BRD4 4832/4885CREBBP 4161/4885
US-20050033076-A1 Preparation of preparing substituted indanones CYP1A2, CYP2J2, IDH3A BRD4 3097/4885CREBBP 2331/4885
US-20030009046-A1 Preparation of preparing substituted indanones CYP1A2, CYP1B1, CYP1A1 BRD4 3045/4885CREBBP 2466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.