SCHEMBL25254239

SCHEMBL25254239

COc1ccc2c(c1)c(CCN)nn2COCC[Si](C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADRB2 P07550 1/20 0.43
▸ DGAT1 O75907 1/20 0.38
▸ HTR6 P50406 4/20 0.36
▸ HTR1D P28221 2/20 0.36
▸ HTR2A P28223 2/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ HTR1A P08908 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ NFKB1 P19838 1/20 0.36
▸ HTR1B P28222 1/20 0.36
▸ HTR2C P28335 1/20 0.36
▸ HTR7 P34969 1/20 0.36
▸ HTR4 Q13639 1/20 0.36
▸ TRPM8 Q7Z2W7 1/20 0.36
▸ BLM P54132 1/20 0.35
▸ PMP22 Q01453 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ TAAR1 Q96RJ0 2/20 0.35
▸ ADRA1A P35348 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25247836 0.85 HTR1A (0.40) DGAT1HTR6CYP1A2HTR1ATSHR
SCHEMBL30565933 0.85 HTR1A (0.40) DGAT1HTR6CYP1A2HTR1ATSHR
SCHEMBL25248599 0.84 HTR2A (0.42) DGAT1HTR6HTR2ACYP1A2GRIK1
SCHEMBL30565949 0.84 HTR2A (0.42) DGAT1HTR6HTR2ACYP1A2GRIK1
SCHEMBL25293730 0.84 HTR6 (0.35) DGAT1HTR6CYP1A2HTR1AGRIK1
SCHEMBL25248211 0.83 HTR6 (0.38) DGAT1HTR6HTR1DHTR2AHTR1A
SCHEMBL25298101 0.83 MTNR1A (0.41) NPC1
SCHEMBL30565955 0.79 BRD4 (0.43) NPC1
SCHEMBL25793072 0.79 BRD4 (0.43) NPC1
SCHEMBL25297650 0.78 PTGER4 (0.40) DGAT1CYP1A2MAPTNPSR1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735425-A1 COMPOUNDS Psylo Pty Ltd (AU) 2026-05-06 — — EP disclosed
US-20250353818-A1 Compounds Psylo Pty Ltd (AU) 2025-11-20 — — US disclosed
US-12428380-B2 Compounds Psylo Pty Ltd (AU) 2025-09-30 — — US disclosed
US-20250214943-A1 Compounds Psylo Pty Ltd (AU) 2025-07-03 — — US disclosed
US-20250163044-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-05-22 — — US disclosed
WO-2025000053-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-01-02 — — WO disclosed
CN-118974044-A Compounds of formula (I) 赛洛私人有限公司 2024-11-15 — — CN disclosed
EP-4452979-A1 COMPOUNDS Psylo Pty Ltd (AU) 2024-10-30 — — EP disclosed
WO-2023115165-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
WO-2023115165-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214943-A1 Compounds NLN, SLC18A2, PYGB ADRB2 1088/4885DGAT1 1102/4885HTR6 54/4885
US-12428380-B2 Compounds NLN, SLC18A2, PYGB ADRB2 1088/4885DGAT1 1102/4885HTR6 54/4885
US-20250163044-A1 COMPOUNDS NLN, SLC18A2, PYGB ADRB2 1088/4885DGAT1 1102/4885HTR6 54/4885
US-20250353818-A1 Compounds NLN, SLC18A2, PYGB ADRB2 1088/4885DGAT1 1102/4885HTR6 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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