Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521394 | 0.80 | RXFP1 (0.40) | RXFP1MAPTTHRBPOLBADORA2A | |
| SCHEMBL563298 | 0.77 | RXFP1 (0.42) | RXFP1MAPTTHRBPOLBADORA2A | |
| SCHEMBL2527116 | 0.74 | ADORA2A (0.38) | ADORA2APDE4AADORA2BPDE4BPDE4C | |
| SCHEMBL563424 | 0.73 | RXFP1 (0.39) | RXFP1MAPTTHRBPOLBADORA2A | |
| SCHEMBL2527293 | 0.69 | PPARG (0.38) | ADORA2AALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2523023 | 0.68 | MAPT (0.38) | RXFP1MAPTPOLBADORA2AL3MBTL1 | |
| SCHEMBL562019 | 0.67 | ADORA2B (0.54) | ADORA2APDE4AADORA2BPDE4BPDE4C | |
| SCHEMBL2531387 | 0.67 | ALDH1A1 (0.34) | ADORA2AADORA2BALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL562181 | 0.66 | ADORA2A (0.41) | ADORA2AADORA2BALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19827228 | 0.65 | KMT2A (0.47) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |