Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527362 | 0.88 | ALDH1A1 (0.32) | PPARGADORA2AALDH1A1PKMTSHR | |
| SCHEMBL2527116 | 0.88 | ADORA2A (0.38) | ADORA2AALDH1A1SMN1; SMN2CNOT7 | |
| SCHEMBL2531387 | 0.87 | ALDH1A1 (0.34) | PPARGADORA2AALDH1A1SMN1; SMN2CNOT7 | |
| SCHEMBL2524833 | 0.87 | PPARG (0.35) | PPARGADORA2AALDH1A1PKMTSHR | |
| SCHEMBL2523023 | 0.86 | MAPT (0.38) | PPARGADORA2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2527271 | 0.86 | MEN1 (0.42) | PPARGADORA2AALDH1A1SMN1; SMN2CNOT7 | |
| SCHEMBL2524932 | 0.85 | HSP90AA1 (0.38) | PPARGALDH1A1PKMMAPK1SMN1; SMN2 | |
| SCHEMBL2529251 | 0.85 | PPARG (0.41) | PPARGADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2528388 | 0.83 | ALDH1A1 (0.35) | ADORA2AALDH1A1SMN1; SMN2CNOT7 | |
| SCHEMBL2528328 | 0.82 | TSHR (0.38) | ADORA2AALDH1A1TSHRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |