Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 5/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527271 | 0.92 | MEN1 (0.42) | ALDH1A1SMN1; SMN2PPARGADORA2AADORA2B | |
| SCHEMBL2523023 | 0.89 | MAPT (0.38) | ALDH1A1SMN1; SMN2PPARGADORA2AADORA2B | |
| SCHEMBL2527293 | 0.87 | PPARG (0.38) | ALDH1A1SMN1; SMN2PPARGADORA2ACNOT7 | |
| SCHEMBL2528388 | 0.87 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL2527116 | 0.86 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2ADORA2AADORA2BTRPA1 | |
| SCHEMBL2524833 | 0.85 | PPARG (0.35) | ALDH1A1SMN1; SMN2PPARGADORA2ACNOT7 | |
| SCHEMBL10182837 | 0.85 | ADORA2B (0.39) | ALDH1A1SMN1; SMN2PPARGADORA2AADORA2B | |
| SCHEMBL2524932 | 0.83 | HSP90AA1 (0.38) | ALDH1A1SMN1; SMN2PPARGCNOT7 | |
| SCHEMBL2527362 | 0.83 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2PPARGADORA2A | |
| SCHEMBL2528328 | 0.82 | TSHR (0.38) | ALDH1A1SMN1; SMN2ADORA2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |