Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17123793 | 0.88 | CHRNB4 (0.50) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL796223 | 0.86 | CHRNB4 (0.48) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL24990313 | 0.82 | CHRNB2 (0.46) | KCNH2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3040992 | 0.81 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| SCHEMBL26154104 | 0.78 | PARP10 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| SCHEMBL23091980 | 0.76 | CHRNB2 (0.40) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| SCHEMBL29479465 | 0.76 | CHRNB2 (0.40) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| Hydrochloric Acid SCHEMBL26607615 | 0.74 | KDM1A (0.44) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL26607617 | 0.74 | KDM1A (0.44) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL15151146 | 0.74 | MAOA (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
| CN-115989228-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | CBR3, BRIX1, CCNY | SLC6A2 4620/4885SLC6A4 4365/4885SLC6A3 4359/4885 |
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | SLC6A2 4620/4885SLC6A4 4365/4885SLC6A3 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.