SCHEMBL17123793

SCHEMBL17123793

Fc1ccc(C2CNC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 4/20 0.50
CHRNA3 P32297 4/20 0.50
CHRNB2 P17787 4/20 0.50
CHRNA4 P43681 4/20 0.50
KDM1A O60341 2/20 0.43
HTR3A P46098 1/20 0.42
CHRNA7 P36544 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
ATM Q13315 1/20 0.40
SLC6A2 P23975 2/20 0.38
SLC6A3 Q01959 2/20 0.38
MAP1LC3B Q9GZQ8 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
SLC6A4 P31645 1/20 0.38
HTR2B P41595 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL796223 0.98 CHRNB4 (0.48) CHRNB4CHRNA3CHRNB2CHRNA4KDM1A
SCHEMBL24990313 0.93 CHRNB2 (0.46) CHRNB4CHRNA3CHRNB2CHRNA4KDM1A
SCHEMBL25255641 0.88 SLC6A2 (0.45) CHRNB4CHRNA3CHRNB2CHRNA4KDM1A
Hydrochloric Acid SCHEMBL26607617 0.85 KDM1A (0.44) CHRNB4CHRNA3CHRNB2CHRNA4KDM1A
Hydrochloric Acid SCHEMBL26607615 0.85 KDM1A (0.44) CHRNB4CHRNA3CHRNB2CHRNA4KDM1A
SCHEMBL2937820 0.82 HTR3A (0.66) HTR3AHTR2C
SCHEMBL1828844 0.82 HTR3A (0.66) HTR3AHTR2C
SCHEMBL1707108 0.82 HTR3A (0.66) HTR3AHTR2C
SCHEMBL24127465 0.81 HTR3A (0.53) HTR3ASLC6A2SLC6A3HTR2AHTR2C
SCHEMBL25305280 0.81 HTR3A (0.53) HTR3ASLC6A2SLC6A3HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206722-A1 SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS THE SCRIPPS RESEARCH INSTITUTE 2025-06-26 US disclosed
WO-2025042736-A1 BICYCLIC HETEROCYCLES AS MRGPRX2 ANTAGONISTS INCYTE CORPORATION (US) 2025-02-27 WO disclosed
US-20250059207-A1 6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS 858 THERAPEUTICS, INC. 2025-02-20 US disclosed
CN-119403551-A Small molecule inhibitors of TEA domain family members 斯克里普斯研究学院 2025-02-07 CN disclosed
EP-4496570-A2 SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS The Scripps Research Institute (US) 2025-01-29 EP disclosed
US-20240400578-A1 SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS UNION therapeutics A/S (DK) 2024-12-05 US disclosed
WO-2024201248-A1 COMPOUNDS AND METHODS FOR DEGRADING GSPT1 PIN THERAPEUTICS, INC. (KR) 2024-10-03 WO disclosed
US-11981681-B2 Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors UNION therapeutics A/S (DK) 2024-05-14 US disclosed
CN-111727191-B Substituted azetidine dihydro-thienopyridines and their use as phosphodiesterase inhibitors 联合疗法公司 2024-01-05 CN disclosed
EP-3724194-B1 SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS UNION THERAPEUTICS AS (DK) 2023-12-27 EP disclosed
WO-2019115776-A1 SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2019-06-20 WO disclosed
WO-2019115774-A1 SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2019-06-20 WO disclosed
WO-2019034702-A1 NOVEL COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-02-21 WO disclosed
US-9993477-B2 Substituted imidazo[1,5-a]pyrazines as PDE9 inhibitors H. LUNDBECK A/S (DK) 2018-06-12 US disclosed
US-20180118721-A1 PYRIMIDINE DERIVATIVES MERCK PATENT GMBH (DE) 2018-05-03 US disclosed
US-20180118721-A1 PYRIMIDINE DERIVATIVES MERCK PATENT GMBH (DE) 2018-05-03 US disclosed
US-20170173018-A1 SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS PDE9 INHIBITORS SUNDIA MEDITECH COMPANY, LTD. (CN) 2017-06-22 US disclosed
US-9643970-B2 Substituted imidazo [1,5-a]pyrazines as PDE9 inhibitors H. LUNDBECK A/S (DK) 2017-05-09 US disclosed
WO-2016128140-A1 PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER MERCK PATENT GMBH (DE) 2016-08-18 WO disclosed
US-20150274736-A1 PDE9i with imidazo pyrazinone backbone SUNDIA MEDITECH COMPANY, LTD. (CN) 2015-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206722-A1 SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS YAP1, TEAD1, TEAD2 CHRNB4 4253/4885CHRNA3 4215/4885CHRNB2 3892/4885
US-20180118721-A1 PYRIMIDINE DERIVATIVES MTHFD1, TYMS, DPYD CHRNB4 4780/4885CHRNA3 4643/4885CHRNB2 4639/4885
US-20250059207-A1 6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS METTL3, METTL16, TPMT CHRNB4 4619/4885CHRNA3 4464/4885CHRNB2 4683/4885
US-20150274736-A1 PDE9i with imidazo pyrazinone backbone PDE9A, PDE5A, PDE12 CHRNB4 187/4885CHRNA3 126/4885CHRNB2 214/4885
US-20170173018-A1 SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS PDE9 INHIBITORS PDE9A, PDE12, PDE5A CHRNB4 673/4885CHRNA3 314/4885CHRNB2 506/4885
US-11981681-B2 Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors PDE2A, PDE3A, PDE3B CHRNB4 1223/4885CHRNA3 942/4885CHRNB2 935/4885
US-20240400578-A1 SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS PDE2A, PDE3A, PDE3B CHRNB4 1223/4885CHRNA3 942/4885CHRNB2 935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.