Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.54 |
| ▸ | HRH1 | P35367 | 7/20 | 0.54 |
| ▸ | HTR1A | P08908 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.49 |
| ▸ | DRD1 | P21728 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Depramine SCHEMBL2108027 | 0.80 | HTR1A (0.73) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Depramine SCHEMBL29489714 | 0.80 | HTR1A (0.73) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Tienopramine SCHEMBL29388629 | 0.68 | HTR1A (0.57) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL6118138 | 0.67 | SLC6A4 (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL29350100 | 0.67 | SLC6A4 (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL17004048 | 0.67 | SLC6A4 (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL34282 | 0.67 | SLC6A4 (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL41765 | 0.66 | LMNA (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL28759733 | 0.66 | LMNA (1.00) | SLC6A4HRH1HTR1ADRD2HTR2A | |
| Imipramine SCHEMBL29040915 | 0.66 | SLC6A4 (0.97) | SLC6A4HRH1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883863-B1 | Safety of psuedoephedrine drug products | PISGAH LABORATORIES, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8039461-B1 | Physical states of a pharmaceutical drug substance | PISGAH LABORATORIES, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-7718649-B1 | amorphous and morphologically pure imipramine pamoate characterized by differential scanning calorimetry, fourier transform infrared, and powder x-ray diffraction; combining the pH adjusted solutions of imipramine hydrochloride with disodium pamoate, warming, cooling and precipitating solids | PISGAH LABS, INC. (US) | 2010-05-18 | — | — | US | disclosed |