Depramine

Depramine

SCHEMBL29489714

CN(C)CCCN1c2ccccc2C=Cc2ccccc21

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 8/20 0.73
DRD2 P14416 8/20 0.73
HRH1 P35367 8/20 0.73
HTR2A P28223 7/20 0.73
SLC6A4 P31645 7/20 0.73
HTR6 P50406 6/20 0.73
CYP2D6 P10635 8/20 0.63
CYP1A2 P05177 7/20 0.63
LMNA P02545 6/20 0.63
MAPT P10636 6/20 0.63
CHRM2 P08172 5/20 0.63
CHRM1 P11229 5/20 0.63
ADRA2B P18089 5/20 0.63
ADRA2C P18825 5/20 0.63
DRD1 P21728 5/20 0.63
SLC6A2 P23975 5/20 0.63
ADRA1A P35348 5/20 0.63
OPRM1 P35372 5/20 0.63
DRD3 P35462 5/20 0.63
KCNH2 Q12809 5/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Depramine SCHEMBL2108027 1.00 HTR1A (0.73) HTR1ADRD2HRH1HTR2ASLC6A4
Tienopramine SCHEMBL29388629 0.86 HTR1A (0.57) HTR1ADRD2HRH1HTR2ASLC6A4
SCHEMBL2525591 0.80 SLC6A4 (0.54) HTR1ADRD2HRH1HTR2ASLC6A4
SCHEMBL12265301 0.79 CYP2D6 (0.66) HTR1ADRD2HRH1HTR2ASLC6A4
SCHEMBL10613637 0.78 PTGS1 (0.53) HTR1ADRD2HRH1HTR2ASLC6A4
Promazine SCHEMBL140489 0.77 CYP2D6 (1.00) HTR1ADRD2HRH1HTR2ASLC6A4
Imipramine SCHEMBL17004048 0.77 SLC6A4 (1.00) HTR1ADRD2HRH1HTR2ASLC6A4
Imipramine SCHEMBL34282 0.77 SLC6A4 (1.00) HTR1ADRD2HRH1HTR2ASLC6A4
Promazine SCHEMBL9052694 0.77 CYP2D6 (1.00) HTR1ADRD2HRH1HTR2ASLC6A4
Imipramine SCHEMBL6118138 0.77 SLC6A4 (1.00) HTR1ADRD2HRH1HTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12269936-B2 Cellulose processing COÖPERATIE KONINKLIJKE COSUN U.A. (NL) 2025-04-08 US disclosed
US-20230357542-A1 CELLULOSE PROCESSING COÖPERATIE KONINKLIJKE COSUN U.A. (NL) 2023-11-09 US disclosed
US-11739197-B2 Cellulose processing COÖPERATIE KONINKLIJKE COSUN U.A. (NL) 2023-08-29 US disclosed
CN-115916812-A GIP receptor agonist peptide compounds and uses thereof 武田药品工业株式会社 2023-04-04 CN disclosed
WO-2023282544-A1 PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT 국립암센터 2023-01-12 WO disclosed
US-20220227970-A1 Structuring agents NOURYON CHEMICALS INTERNATIONAL B.V. (NL) 2022-07-21 US disclosed
US-20220213297-A1 COMPOSITIONS COMPRISING FIBRILLATED CELLULOSE AND NON-IONIC CELLULOSE ETHERS NOURYON CHEMICALS INTERNATIONAL B.V (NL) 2022-07-07 US disclosed
EP-3966255-A1 COMPOSITIONS COMPRISING FIBRILLATED CELLULOSE AND NON-IONIC CELLULOSE ETHERS Nouryon Chemicals International B.V. (NL) 2022-03-16 EP disclosed
EP-3966254-A1 STRUCTURING AGENTS Nouryon Chemicals International B.V. (NL) 2022-03-16 EP disclosed