Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29890873 | 0.86 | PTPN11 (0.53) | PTPN11GPR119MAPTACHECKS1B | |
| SCHEMBL21551531 | 0.86 | PTPN11 (0.53) | PTPN11GPR119MAPTACHECKS1B | |
| SCHEMBL30173624 | 0.85 | ALDH1A1 (0.62) | PTPN11GPR119MAPTSMOACHE | |
| SCHEMBL25239083 | 0.85 | ALDH1A1 (0.62) | PTPN11GPR119MAPTSMOACHE | |
| SCHEMBL24120762 | 0.85 | GPR119 (0.53) | PTPN11GPR119MAPTSMOACHE | |
| SCHEMBL27046549 | 0.84 | GPR119 (0.56) | PTPN11GPR119MAPTACHECKS1B | |
| SCHEMBL29890817 | 0.84 | GPR119 (0.56) | PTPN11GPR119MAPTACHECKS1B | |
| SCHEMBL25230495 | 0.83 | GPR119 (0.48) | PTPN11GPR119MAPTSMOACHE | |
| SCHEMBL30173612 | 0.83 | GPR119 (0.48) | PTPN11GPR119MAPTSMOACHE | |
| SCHEMBL21159159 | 0.83 | GPR119 (0.60) | PTPN11GPR119MAPTACHECKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |