Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25230495 | 1.00 | GPR119 (0.48) | GPR119MAPTTP53PTPN11ALDH1A1 | |
| SCHEMBL20231885 | 0.88 | PTPN11 (0.52) | GPR119MAPTPTPN11ALDH1A1NPSR1 | |
| SCHEMBL30166221 | 0.87 | GPR119 (0.55) | GPR119MAPTPTPN11ALDH1A1HTT | |
| SCHEMBL25274946 | 0.87 | GPR119 (0.55) | GPR119MAPTPTPN11ALDH1A1HTT | |
| SCHEMBL25239083 | 0.85 | ALDH1A1 (0.62) | GPR119MAPTPTPN11ALDH1A1ACHE | |
| SCHEMBL30173624 | 0.85 | ALDH1A1 (0.62) | GPR119MAPTPTPN11ALDH1A1ACHE | |
| SCHEMBL25263333 | 0.83 | PTPN11 (0.53) | GPR119MAPTPTPN11ACHEMEN1 | |
| SCHEMBL12480371 | 0.82 | GPR119 (0.56) | GPR119MAPTPTPN11ACHECKS1B | |
| SCHEMBL25689688 | 0.82 | ALDH1A1 (0.63) | MAPTTP53ALDH1A1NPSR1NPC1 | |
| SCHEMBL25215112 | 0.81 | PTPN11 (0.52) | GPR119MAPTPTPN11ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697972-B | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide urea | 维泰瑞隆有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-115697972-A | Receptor-interacting protein 1 inhibitors comprising piperazine heterocyclic amide ureas | 维泰瑞隆有限公司 | 2023-02-03 | — | — | CN | disclosed |