Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573575 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL7849089 | 0.77 | KDM4E (0.58) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL22573664 | 0.75 | KDM4E (0.49) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL11727584 | 0.74 | LMNA (0.49) | ALDH1A1SMN1; SMN2TLR8CYP1A2CYP3A4 | |
| SCHEMBL1899942 | 0.74 | TSHR (0.47) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL28456194 | 0.72 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL26173556 | 0.72 | LMNA (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9ATLR8 | |
| SCHEMBL11622375 | 0.71 | LMNA (0.57) | ALDH1A1SMN1; SMN2RAB9ATLR8CYP1A2 | |
| SCHEMBL9296297 | 0.69 | LMNA (0.41) | ALDH1A1SMN1; SMN2TLR8CYP1A2CYP3A4 | |
| SCHEMBL22573567 | 0.69 | LMNA (0.41) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059183-A1 | PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST | SHANGHAI VISONPHARMA CO., LTD. (CN) | 2025-02-20 | — | — | US | disclosed |
| EP-4446323-A1 | PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST | Shanghai Visonpharma Co., Ltd. (CN) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023104165-A1 | PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST | 上海维申医药有限公司 | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059183-A1 | PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST | TLR7, TLR8, TLR1 | ALDH1A1 2284/4885SMN1; SMN2 4339/4885NPC1 2083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.