Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202270 | 1.00 | DPP4 (0.40) | DPP4DPP7SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL23846299 | 0.84 | DPP4 (0.39) | DPP4DPP7SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL1131712 | 0.82 | DPP4 (0.40) | DPP4DPP7SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL20399024 | 0.81 | KDM1A (0.52) | SMN1; SMN2MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL21531205 | 0.81 | KDM1A (0.52) | SMN1; SMN2MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL24157448 | 0.80 | DPP4 (0.44) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL12765239 | 0.80 | DPP4 (0.44) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL12765238 | 0.80 | DPP4 (0.44) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL22520970 | 0.80 | ITGB3 (0.38) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL12811743 | 0.77 | MEN1 (0.61) | DPP4MEN1ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295131-A1 | INHIBITORS OF RHO-ASSOCIATED COILED-COIL KINASE | ANGION BIOMEDICA CORP. | 2023-09-21 | — | — | US | disclosed |
| EP-4185579-A1 | INHIBITORS OF RHO-ASSOCIATED COILED-COIL KINASE | Angion Biomedica Corp. (US) | 2023-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295131-A1 | INHIBITORS OF RHO-ASSOCIATED COILED-COIL KINASE | ROCK1, ROCK2, RHOA | DPP4 4718/4885DPP7 3845/4885SMN1; SMN2 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.