Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487486 | 1.00 | CA12 (0.54) | CA12CA9CA1CA3CA4 | |
| SCHEMBL28299982 | 0.98 | CA12 (0.52) | CA12CA9CA1CA3CA4 | |
| SCHEMBL3368797 | 0.85 | CA12 (0.60) | CA12CA9CA1CA3CA4 | |
| SCHEMBL25903990 | 0.79 | GAA (0.50) | CA12CA9CA1CA3CA4 | |
| SCHEMBL25904005 | 0.79 | CDK4 (0.50) | CA12CA9CA1CA3CA4 | |
| SCHEMBL4288324 | 0.78 | CA12 (0.52) | CA12CA9CA1CA3CA4 | |
| SCHEMBL31741308 | 0.77 | HRH4 (0.39) | CA12CA9CA1CA3CA4 | |
| SCHEMBL17951770 | 0.77 | MAPK1 (0.68) | CA12CA9CA1CA3CA4 | |
| SCHEMBL4290533 | 0.75 | CA12 (0.53) | CA12CA9CA1CA3CA4 | |
| SCHEMBL708122 | 0.74 | DAO (0.56) | CA12CA9CA1CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119804705-A | Method for detecting related substances of bripiprazole tablet | 海南通用三洋药业有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-117871704-A | Method for detecting related substances of pirenzepine intermediate | 万全万特制药江苏有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-117871703-A | Method for detecting 7-hydroxy-2-quinolone related substances serving as intermediate of bripiprazole | 万全万特制药江苏有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-114166960-B | Method for detecting substances related to epipiprazole | 西安远大科创医药科技有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-112858524-B | Detection method and application of brexpiprazole related substance | 丽珠集团新北江制药股份有限公司 | 2022-12-20 | — | — | CN | claimed |
| CN-114181202-A | Preparation method of brexpiprazole | 湖南省湘中制药有限公司 | 2022-03-15 | — | — | CN | claimed |
| CN-114166960-A | Detection method of brexpiprazole related substance | 西安远大科创医药科技有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-112858524-A | Detection method and application of brexpiprazole related substance | 丽珠集团新北江制药股份有限公司 | 2021-05-28 | — | — | CN | claimed |
| US-10464931-B2 | Process for the preparation of Quinolin-2(1H)-one derivatives | HONOUR (R&D) (IN) | 2019-11-05 | — | — | US | claimed |
| CN-106645494-B | According to a detection method of the piperazine azoles starting material in relation to substance | 成都百裕制药股份有限公司 | 2019-09-06 | — | — | CN | claimed |
| WO-2018087775-A1 | PROCESSES FOR THE PREPARATION OF 7-{4-[4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL]BUTOXY}QUINOLIN-2(1H)-ONE | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2018-05-17 | — | — | WO | claimed |
| WO-2018015354-A1 | THE METHOD FOR MANUFACTURE OF BREXPIPRAZOLE, INTERMEDIATES USED IN THIS METHOD, AND THE METHOD FOR MANUFACTURE THEREOF | ADAMED SP. Z O.O. (PL) | 2018-01-25 | — | — | WO | claimed |
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2017-11-09 | — | — | US | claimed |
| CN-107098855-A | A kind of method for preparing the quinolinone of 7 hydroxyl 2 | 上海诺星医药科技有限公司 | 2017-08-29 | — | — | CN | claimed |
| WO-2017115287-A1 | PROCESS FOR THE PREPARATION OF QUINOLINE-2(1H)-ONE DERIVATIVES | HONOUR (R&D) (IN) | 2017-07-06 | — | — | WO | claimed |
| CN-106831739-A | It is a kind of for synthesizing according to a preparation method for piperazine azoles | 浙江燎原药业股份有限公司 | 2017-06-13 | — | — | CN | claimed |
| CN-106749007-A | A kind of method for preparing the quinolone of 7 hydroxyl 2 | 沧州那瑞化学科技有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106117750-A | Photodegradable plastics thin film | 芜湖凯奥尔环保科技有限公司 | 2016-11-16 | — | — | CN | claimed |
| CN-106008337-A | Synthesis method of brexpiprazole intermediate 7-(4-chlorobutoxy)-1H-quinoline-2-one | 山东川成医药股份有限公司 | 2016-10-12 | — | — | CN | claimed |
| CN-105399736-A | Novel preparation method of brexpiprazole | ANHUI YIXINMING PHARMACEUTICAL TECH CO LTD | 2016-03-16 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CYP4Z1, CYP4X1, CYP4B1 | CA12 1992/4885CA9 2777/4885CA1 1724/4885 |
| US-10464931-B2 | Process for the preparation of Quinolin-2(1H)-one derivatives | UGT1A1, CYP1A2, CYP1A1 | CA12 4414/4885CA9 3962/4885CA1 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.