Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2531387 | 0.92 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL2524833 | 0.90 | PPARG (0.35) | ALDH1A1L3MBTL1POLBSMN1; SMN2PPARG | |
| SCHEMBL2524932 | 0.88 | HSP90AA1 (0.38) | ALDH1A1HTTSMN1; SMN2MAOBPPARG | |
| SCHEMBL2527293 | 0.86 | PPARG (0.38) | ALDH1A1SMN1; SMN2PPARGCNOT7ADORA2A | |
| SCHEMBL10183558 | 0.86 | MEN1 (0.40) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL2528388 | 0.86 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2CNOT7ADORA2BADORA2A | |
| SCHEMBL2523023 | 0.83 | MAPT (0.38) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL2527116 | 0.83 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2CNOT7ADORA2BADORA2A | |
| SCHEMBL562575 | 0.83 | MEN1 (0.42) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL2527362 | 0.82 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2PPARGADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |