Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523023 | 0.91 | MAPT (0.38) | RXFP1PPARGSMN1; SMN2MAPTHTT | |
| SCHEMBL2524833 | 0.91 | PPARG (0.35) | PPARGTP53SMN1; SMN2LMNAMAPT | |
| SCHEMBL2527271 | 0.88 | MEN1 (0.42) | PPARGSMN1; SMN2HTTADORA3CNOT7 | |
| SCHEMBL2527411 | 0.86 | ADORA2B (0.40) | HSP90AA1HSP90AB1PPARGPPARASMN1; SMN2 | |
| SCHEMBL2528328 | 0.86 | TSHR (0.38) | TP53SMN1; SMN2LMNAMAPTCNOT7 | |
| SCHEMBL2527293 | 0.85 | PPARG (0.38) | PPARGSMN1; SMN2CNOT7PKMALDH1A1 | |
| SCHEMBL2527116 | 0.84 | ADORA2A (0.38) | SMN1; SMN2CNOT7ALDH1A1 | |
| SCHEMBL2531387 | 0.83 | ALDH1A1 (0.34) | PPARGSMN1; SMN2CNOT7ALDH1A1 | |
| SCHEMBL562075 | 0.82 | ADORA2A (0.36) | HSP90AA1HSP90AB1RXFP1PPARGPPARA | |
| SCHEMBL2527362 | 0.81 | ALDH1A1 (0.32) | PPARGSMN1; SMN2PKMALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |