Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31421699 | 0.88 | HDAC6 (0.64) | MC4RKCNH2HDAC4HDAC6HDAC1 | |
| SCHEMBL31666906 | 0.85 | MC4R (0.72) | MC4RKCNH2HDAC4HDAC6HDAC1 | |
| SCHEMBL30457945 | 0.85 | HDAC4 (0.47) | MC4RKCNH2HDAC4HDAC6HDAC1 | |
| SCHEMBL25278377 | 0.80 | MC4R (0.59) | MC4RKCNH2 | |
| SCHEMBL14918363 | 0.77 | HDAC6 (0.57) | HDAC4HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL25435475 | 0.76 | HDAC4 (0.53) | MC4RKCNH2HDAC4HDAC6HDAC1 | |
| SCHEMBL25437281 | 0.76 | MC4R (0.55) | MC4RKCNH2 | |
| SCHEMBL25422750 | 0.76 | MC4R (0.67) | MC4RKCNH2 | |
| Hydrochloric Acid SCHEMBL30457709 | 0.75 | HDAC4 (0.52) | MC4RKCNH2HDAC4HDAC6HDAC1 | |
| SCHEMBL25420312 | 0.75 | MC4R (0.55) | MC4RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |