Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | MC4R | P32245 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31421699 | 0.86 | HDAC6 (0.64) | HDAC4HDAC6MC4RKCNH2HDAC8 | |
| SCHEMBL25277175 | 0.85 | MC4R (0.51) | HDAC4HDAC6MC4RKCNH2HDAC8 | |
| SCHEMBL30458624 | 0.82 | MC4R (0.60) | MC4RKCNH2MAP4K4 | |
| SCHEMBL31666906 | 0.80 | MC4R (0.72) | HDAC4HDAC6MC4RKCNH2HDAC1 | |
| SCHEMBL30458637 | 0.78 | NOS2 (0.46) | MC4RKCNH2MAP4K4 | |
| SCHEMBL21825201 | 0.74 | HDAC4 (0.52) | HDAC4HDAC6HDAC8HDAC1 | |
| SCHEMBL23292322 | 0.73 | NOS2 (0.52) | MAP4K4 | |
| SCHEMBL23292432 | 0.70 | CCNK (0.51) | MAP4K4 | |
| SCHEMBL25435475 | 0.70 | HDAC4 (0.53) | HDAC4HDAC6MC4RKCNH2HDAC8 | |
| SCHEMBL31421671 | 0.69 | MC4R (0.69) | HDAC4HDAC6MC4RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444708-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |