Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30183105 | 1.00 | PNMT (0.46) | PNMTDRD2DRD3HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL25281366 | 0.98 | PNMT (0.45) | PNMTDRD2DRD3HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL31186539 | 0.98 | PNMT (0.45) | PNMTDRD2DRD3HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL31186449 | 0.86 | KDM1A (0.41) | PNMTDRD2DRD3 | |
| SCHEMBL31310249 | 0.83 | PNMT (0.33) | PNMTDRD2DRD3CYP11B2 | |
| SCHEMBL19711547 | 0.74 | CHRNB2 (0.41) | PNMTCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL19667229 | 0.74 | PNMT (0.44) | PNMTCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL19684585 | 0.74 | CHRNB2 (0.41) | PNMTCHRNB2CHRNA4ADRA2AADRA2B | |
| SCHEMBL30406342 | 0.73 | CYP11B2 (0.51) | CYP11B2 | |
| SCHEMBL3947001 | 0.73 | CYP11B2 (0.56) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023105491-A1 | 5,6,7,8-TETRAHYDRO-2,6-NAPHTHYRIDINE DERIVATIVES AS CANCER THERAPEUTICS | VRISE THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |