Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2528388 | 0.88 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2ADORA2ACNOT7 | |
| SCHEMBL2523023 | 0.87 | MAPT (0.38) | MAPK1TDP1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL2524932 | 0.86 | HSP90AA1 (0.38) | MAPK1ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL2527362 | 0.85 | ALDH1A1 (0.32) | TSHRMAPK1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2525205 | 0.85 | TSHR (0.38) | TSHRMAPK1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2527116 | 0.85 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2ADORA2ACNOT7 | |
| SCHEMBL2524833 | 0.83 | PPARG (0.35) | TSHRMAPK1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2527293 | 0.82 | PPARG (0.38) | TSHRMAPK1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2531387 | 0.82 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2MEN1KMT2AADORA2A | |
| SCHEMBL562035 | 0.81 | ADORA2A (0.37) | TSHRMAPK1TDP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |