Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | GART | P22102 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25257994 | 1.00 | TYMS (0.40) | TYMSDHFRGARTSUCNR1MEN1 | |
| SCHEMBL24344795 | 0.94 | TDP1 (0.36) | DHFRMEN1KMT2APAX8TDP1 | |
| SCHEMBL25298843 | 0.87 | DHFR (0.46) | DHFR | |
| SCHEMBL25251194 | 0.87 | DHFR (0.46) | DHFR | |
| SCHEMBL31143716 | 0.85 | TYMS (0.45) | TYMSDHFRGART | |
| SCHEMBL25301066 | 0.82 | DHFR (0.48) | TYMSDHFR | |
| SCHEMBL25301067 | 0.82 | DHFR (0.48) | TYMSDHFR | |
| SCHEMBL24343802 | 0.81 | TDP1 (0.40) | DHFRKMT2APAX8TDP1MAPT | |
| SCHEMBL24343391 | 0.79 | TYMS (0.39) | TYMSDHFRGART | |
| SCHEMBL25725125 | 0.78 | TYMS (0.41) | TYMSDHFRGART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023126297-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-07-06 | — | — | WO | disclosed |