Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LCAT | P04180 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.45 |
| ▸ | ITGAL | P20701 | 3/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1990732 | 0.93 | MALT1 (0.59) | MALT1CHRM4PDE4APDE4BPDE4C | |
| Trifluoroacetic Acid SCHEMBL30338667 | 0.92 | MALT1 (0.52) | MALT1CHRM4PDE4APDE4BPDE4C | |
| Trifluoroacetic Acid SCHEMBL1025514 | 0.85 | FFAR4 (0.56) | MALT1CHRM4HRH3LCATDPP4 | |
| Trifluoroacetic Acid SCHEMBL30338657 | 0.80 | GPR119 (0.54) | PDE4APDE4BPDE4CPDE4DNOTUM | |
| Trifluoroacetic Acid SCHEMBL30338868 | 0.80 | DPP4 (0.49) | DPP4DPP7DPP8DPP9ITGB2 | |
| Acetic Acid SCHEMBL1025513 | 0.79 | HRH3 (0.61) | MALT1CHRM4HRH3LCATUSP30 | |
| SCHEMBL25818614 | 0.79 | KDM4E (0.58) | MALT1CHRM4HRH3THRBUSP30 | |
| SCHEMBL5220987 | 0.77 | USP30 (0.57) | MALT1CHRM4HRH3LCATDPP4 | |
| SCHEMBL13622626 | 0.77 | CHRM4 (0.56) | MALT1CHRM4HRH3LCATDPP4 | |
| Trifluoroacetic Acid SCHEMBL29048229 | 0.77 | KDM4E (0.52) | CHRM4PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | RIPK1, RIPK4, RIPK2 | MALT1 813/4885CHRM4 4435/4885PDE4A 1469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.