Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 9/20 | 0.69 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31140004 | 1.00 | SMARCA2 (0.69) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL9599834 | 0.88 | SMARCA2 (0.86) | SMARCA2SMARCA4CNR1S1PR2ALDH1A1 | |
| SCHEMBL25832379 | 0.88 | SMARCA2 (0.66) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL119685 | 0.84 | SMARCA2 (0.79) | SMARCA2SMARCA4KDRCNR1MAPT | |
| SCHEMBL31139994 | 0.84 | SMARCA2 (0.65) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL25300737 | 0.84 | SMARCA2 (0.65) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL27968802 | 0.83 | SMARCA2 (0.72) | SMARCA2SMARCA4CNR1MAPTMEN1 | |
| SCHEMBL22125200 | 0.82 | SMARCA2 (1.00) | SMARCA2SMARCA4MAPTSMN1; SMN2MEN1 | |
| SCHEMBL22125520 | 0.82 | SMARCA2 (0.76) | SMARCA2SMARCA4CNR1S1PR2MAPT | |
| SCHEMBL11047103 | 0.81 | SMARCA2 (0.79) | SMARCA2SMARCA4KDRCNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163024-A1 | CHEMICAL TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) AND USE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2025-05-22 | — | — | US | disclosed |
| EP-4460306-A2 | TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) | Dana-Farber Cancer Institute, Inc. (US) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023133260-A2 | CHEMICAL TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) AND USE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| WO-2023133260-A2 | CHEMICAL TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) AND USE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163024-A1 | CHEMICAL TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) AND USE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) | SMARCE1, SMARCA4, SMARCA2 | SMARCA2 3/4885SMARCA4 2/4885KDR 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.