Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 9/20 | 0.66 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.66 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25301796 | 0.88 | SMARCA2 (0.69) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL31140004 | 0.88 | SMARCA2 (0.69) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL9599834 | 0.86 | SMARCA2 (0.86) | SMARCA2SMARCA4CNR1S1PR2MEN1 | |
| SCHEMBL119685 | 0.81 | SMARCA2 (0.79) | SMARCA2SMARCA4KDRCNR1MEN1 | |
| SCHEMBL25300737 | 0.81 | SMARCA2 (0.65) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL31139994 | 0.81 | SMARCA2 (0.65) | SMARCA2SMARCA4KDRCNR1S1PR2 | |
| SCHEMBL22125200 | 0.80 | SMARCA2 (1.00) | SMARCA2SMARCA4MEN1KMT2ALMNA | |
| SCHEMBL22125520 | 0.80 | SMARCA2 (0.76) | SMARCA2SMARCA4CNR1S1PR2MEN1 | |
| SCHEMBL11047103 | 0.78 | SMARCA2 (0.79) | SMARCA2SMARCA4KDRCNR1MEN1 | |
| SCHEMBL27968802 | 0.78 | SMARCA2 (0.72) | SMARCA2SMARCA4CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133260-A2 | CHEMICAL TARGETING SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4 (SMARCA4) AND USE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-07-13 | — | — | WO | disclosed |