Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18209300 | 0.87 | EDNRB (0.42) | KMT2AMEN1 | |
| SCHEMBL18209322 | 0.80 | HSD17B10 (0.49) | LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL2525409 | 0.73 | HSD17B10 (0.48) | ESR1ESR2MAOAUGT1A1MAOB | |
| SCHEMBL18215445 | 0.72 | EDNRB (0.44) | KMT2AMEN1 | |
| SCHEMBL2522963 | 0.71 | HSD17B1 (0.41) | ESR1ESR2MAOAUGT1A1MAOB | |
| SCHEMBL23784644 | 0.69 | TGM2 (0.36) | — | |
| SCHEMBL12214779 | 0.69 | CYP1A2 (0.51) | ESR1ESR2GAAKMT2AKDM4E | |
| SCHEMBL17711719 | 0.66 | MKNK1 (0.43) | LMNAGAAMAPTKMT2AKDM4E | |
| SCHEMBL6451059 | 0.65 | TYR (0.47) | LMNAGAAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL6451064 | 0.65 | TYR (0.47) | LMNAGAAMAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039484-B2 | Antidiabetic bicyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2011-10-18 | — | — | US | disclosed |