Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.78 |
| ▸ | HPGD | P15428 | 6/20 | 0.78 |
| ▸ | GAA | P10253 | 5/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.78 |
| ▸ | GLA | P06280 | 4/20 | 0.78 |
| ▸ | NPC1 | O15118 | 4/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | RORC | P51449 | 7/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308120 | 0.90 | MAPT (0.82) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL24185446 | 0.85 | RORC (1.00) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL25263423 | 0.85 | RORC (0.81) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL3735493 | 0.84 | RORC (1.00) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL5390777 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL25306302 | 0.82 | ALDH1A1 (0.68) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL24185748 | 0.81 | RORC (1.00) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL12692491 | 0.80 | RORC (0.78) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL13970848 | 0.80 | ALDH1A1 (0.71) | ALDH1A1MAPTGAAKDM4EMEN1 | |
| SCHEMBL25307540 | 0.80 | RORC (1.00) | ALDH1A1MAPTHPGDGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219925-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) | 2023-07-13 | — | — | US | claimed |
| CN-113912563-A | Benzo five-membered nitrogen heterocyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-01-11 | — | — | CN | claimed |
| US-20230219925-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) | 2023-07-13 | — | — | US | disclosed |
| US-20230219925-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) | 2023-07-13 | — | — | US | disclosed |
| US-20230219925-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219925-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | RORC, RORB, RORA | ALDH1A1 2704/4885MAPT 620/4885HPGD 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.