SCHEMBL25313673

SCHEMBL25313673

NC(=O)C1C(=O)N(c2cccc(F)c2F)CC1c1ccc(F)c(F)c1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 11/20 0.36
AADAT Q8N5Z0 1/20 0.34
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
ADAMTS5 Q9UNA0 3/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A3 Q01959 1/20 0.32
TSHR P16473 1/20 0.32
SIRT2 Q8IXJ6 1/20 0.32
SIRT1 Q96EB6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21638332 0.91 MEN1 (0.39) KDM1AHTR2AHTR2CHTR2BADAMTS5
SCHEMBL25317840 0.85 HTR2B (0.38) KDM1AHTR2AHTR2CHTR2BTSHR
SCHEMBL25315680 0.84 SIRT2 (0.38) AADATSIRT2SIRT1
SCHEMBL25318566 0.84 REN (0.35) AADAT
SCHEMBL25315349 0.80 HRH3 (0.37) KDM1A
SCHEMBL25313489 0.80 RPS6KB1 (0.38) AADATHTR2AHTR2CHTR2B
SCHEMBL22493139 0.78 FPR2 (0.39)
SCHEMBL22493133 0.78 FPR2 (0.39)
SCHEMBL25319499 0.77 ALDH1A1 (0.40) HTR2AHTR2CHTR2BTSHRSIRT2
SCHEMBL21638330 0.77 ALDH1A1 (0.40) HTR2AHTR2CHTR2BTSHRSIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3890487-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2024-06-12 EP claimed
EP-3923724-B1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-07-26 EP claimed