Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 5/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30550891 | 1.00 | HTR1A (0.33) | HTR1AHTR2ADRD2TIPARPGRM2 | |
| SCHEMBL31058433 | 0.84 | LMNA (0.40) | TIPARPGRM2 | |
| SCHEMBL25898093 | 0.83 | LMNA (0.41) | TIPARPGRM2 | |
| SCHEMBL30550698 | 0.82 | TIPARP (0.35) | TIPARPGRM2 | |
| Hydrochloric Acid SCHEMBL31058409 | 0.82 | SIK2 (0.38) | TIPARPGRM2 | |
| SCHEMBL25320350 | 0.82 | TIPARP (0.35) | TIPARPGRM2 | |
| Hydrochloric Acid SCHEMBL26658801 | 0.82 | SIK2 (0.38) | TIPARPGRM2 | |
| SCHEMBL25320077 | 0.81 | TIPARP (0.32) | TIPARP | |
| SCHEMBL25321271 | 0.80 | TIPARP (0.33) | DRD2TIPARP | |
| SCHEMBL25321451 | 0.80 | TIPARP (0.37) | TIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459922-B2 | PARP7 inhibitors | GILEAD SCIENCES, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459922-B2 | PARP7 inhibitors | PARP1, PARP11, PARP2 | HTR1A 1056/4885HTR2A 2837/4885DRD2 2592/4885 |
| US-20230365529-A1 | PARP7 INHIBITORS | PARP1, PARP11, PARP2 | HTR1A 1056/4885HTR2A 2837/4885DRD2 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.