Sugi Predict

Sugi Predict / Compounds / SCHEMBL253210

SCHEMBL253210

SCHEMBL253210

CCCCCC1=NOc2ccccc2C1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ MAOA P21397 1/20 0.36
▸ MAOB P27338 1/20 0.36
▸ LIPG Q9Y5X9 1/20 0.36
▸ KCNH2 Q12809 1/20 0.35
▸ DRD2 P14416 1/20 0.35
▸ SLC6A2 P23975 1/20 0.35
▸ HTR2A P28223 1/20 0.35
▸ HTR2C P28335 1/20 0.35
▸ SLC6A4 P31645 1/20 0.35
▸ CYP1A1 P04798 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ SIGMAR1 Q99720 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9052322 0.89 MAOA (0.39) CYP2D6ALDH1A1CYP1A2CYP2C19MAOA
SCHEMBL2596954 0.80 MAOA (0.31) MAOAMAOB
SCHEMBL2596963 0.80 MAOA (0.31) MAOAMAOB
SCHEMBL2596951 0.80 MAOA (0.31) MAOAMAOB
SCHEMBL9559375 0.79 SMN1; SMN2 (0.45) CYP2D6ALDH1A1CYP1A2CYP2C19DRD2
SCHEMBL8706455 0.79 MAOA (0.39) MAOAMAOB
SCHEMBL17868865 0.77 ALDH1A1 (0.35) ALDH1A1MAOAMAOBTDP1L3MBTL1
SCHEMBL16823486 0.75 MAOA (0.47) ALDH1A1MAOAMAOBHTR2AHTR2C
SCHEMBL9433814 0.74 SIGMAR1 (0.45) DRD2SLC6A4SIGMAR1
Propionic Acid SCHEMBL16830271 0.73 SORT1 (0.36) ALDH1A1CYP1A2CYP2C19MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240100023-A1 Compositions and Methods For Treating Spinal Cord Injuries LIPPA ARNOLD S (US) 2024-03-28 — — US claimed
US-20230373982-A1 Compositions And Methods For Treating Attention Deficit Disorders LIPPA ARNOLD STAN (US) 2023-11-23 — — US claimed
US-20230129330-A1 Compositions And Methods For Treating Attention Deficit Disorders LIPPA ARNOLD STAN (US) 2023-04-27 — — US claimed
CN-114478576-A Synthetic method of spiroheterocyclic compound 河南农业大学 2022-05-13 — — CN claimed
US-20210340130-A1 Compositions and methods for treating attention deficit disorders LIPPA ARNOLD STAN (US) 2021-11-04 — — US claimed
US-20190112300-A1 Compositions And Methods For Treating Attention Deficit Disorders LIPPA ARNOLD STAN (US) 2019-04-18 — — US claimed
EP-3436021-A1 COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDERS RespireRx Pharmaceuticals Inc. (US) 2019-02-06 — — EP claimed
WO-2018009256-A1 COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDERS RESPIRERX PHARMACEUTICALS, INC. (US) 2018-01-11 — — WO claimed
US-20240100023-A1 Compositions and Methods For Treating Spinal Cord Injuries LIPPA ARNOLD S (US) 2024-03-28 — — US disclosed
US-20230373982-A1 Compositions And Methods For Treating Attention Deficit Disorders LIPPA ARNOLD STAN (US) 2023-11-23 — — US disclosed
CN-116836180-A Nitrogen and oxygen hetero-polycyclic aromatic hydrocarbon and synthetic method and application thereof 河南农业大学 2023-10-03 — — CN disclosed
US-20230129330-A1 Compositions And Methods For Treating Attention Deficit Disorders LIPPA ARNOLD STAN (US) 2023-04-27 — — US disclosed
CN-114716454-A Nitrogen and oxa condensed ring aromatic hydrocarbon and synthetic method thereof 河南农业大学 2022-07-08 — — CN disclosed
CN-114478576-A Synthetic method of spiroheterocyclic compound 河南农业大学 2022-05-13 — — CN disclosed
EP-1067935-A4 ACYLBENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE(S) UNIV CALIFORNIA (US) 2001-10-04 — — EP disclosed
CN-1306427-A Acylbenzoxazines for enhancing synaptic response(s) UNIV CALIFORNIA (US) 2001-08-01 — — CN disclosed
EP-1067935-A1 ACYLBENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE(S) The Regents of the University of California (US) 2001-01-17 — — EP disclosed
US-6124278-A COGNITION ACTIVATORS FOR LEARNING/MEMORY ENHANCEMENT AND TREATMENT OF BRAIN/PSYCHOLOGICAL DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-09-26 — — US disclosed
US-6124278-A COGNITION ACTIVATORS FOR LEARNING/MEMORY ENHANCEMENT AND TREATMENT OF BRAIN/PSYCHOLOGICAL DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-09-26 — — US disclosed
WO-1999051240-A1 ACYLBENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-10-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210340130-A1 Compositions and methods for treating attention deficit disorders GRIN2A, GRIN2C, GRM2 CYP2D6 4706/4885ALDH1A1 1104/4885CYP1A2 4346/4885
US-20240100023-A1 Compositions and Methods For Treating Spinal Cord Injuries CHAT, NTRK2, GMFG CYP2D6 4834/4885ALDH1A1 581/4885CYP1A2 4506/4885
US-20230129330-A1 Compositions And Methods For Treating Attention Deficit Disorders GRIN2A, GRIN2C, GRM2 CYP2D6 4706/4885ALDH1A1 1104/4885CYP1A2 4346/4885
US-20230373982-A1 Compositions And Methods For Treating Attention Deficit Disorders GRIN2A, GRIN2C, GRM2 CYP2D6 4706/4885ALDH1A1 1104/4885CYP1A2 4346/4885
US-20190112300-A1 Compositions And Methods For Treating Attention Deficit Disorders GRIN2A, GRIN2C, GRM2 CYP2D6 4706/4885ALDH1A1 1104/4885CYP1A2 4346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.