Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30551554 | 0.87 | NOS3 (0.39) | EGFRALDH1A1HPGDTP53MAPT | |
| SCHEMBL25320083 | 0.87 | NOS3 (0.39) | EGFRALDH1A1HPGDTP53MAPT | |
| SCHEMBL25320073 | 0.87 | NOS3 (0.39) | EGFRALDH1A1HPGDTP53MAPT | |
| Trifluoroacetic Acid SCHEMBL25324225 | 0.86 | NPC1 (0.39) | ALDH1A1HPGDCCR2LMNAMAPT | |
| Trifluoroacetic Acid SCHEMBL25322512 | 0.81 | CHRNB4 (0.44) | CCR2SMN1; SMN2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL25322818 | 0.80 | ABL1 (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL25325844 | 0.79 | LMNA (0.45) | ALDH1A1HPGDTP53LMNAMAPK1 | |
| Trifluoroacetic Acid SCHEMBL25324505 | 0.78 | BACE1 (0.36) | — | |
| SCHEMBL24366285 | 0.77 | KDM1A (0.37) | EGFRTSHR | |
| SCHEMBL24363895 | 0.77 | HSD17B1 (0.38) | TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |