Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SAT1 | P21673 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9329994 | 0.96 | TP53 (0.57) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL3213311 | 0.92 | — | — | |
| Diethylamine SCHEMBL10970436 | 0.90 | TP53 (0.50) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL28282252 | 0.88 | — | — | |
| Diethylamine SCHEMBL509438 | 0.88 | — | — | |
| Hexane SCHEMBL27802092 | 0.87 | TSHR (0.48) | TP53CYP2C19MEN1GLAKMT2A | |
| Diethylamine SCHEMBL27475901 | 0.85 | TP53 (0.44) | TP53TSHRALDH1A1 | |
| Diethylamine SCHEMBL981472 | 0.84 | — | — | |
| Diethylamine SCHEMBL4046893 | 0.84 | — | — | |
| Diethylamine SCHEMBL11583123 | 0.84 | TP53 (0.73) | TP53CYP2C19MEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109180765-A | A kind of pregnane type steroid alkaloid and its preparation method and application | 贵阳中医学院 | 2019-01-11 | — | — | CN | claimed |
| CN-102276624-B | Olanzapine related substance and preparation method as well as high-efficiency liquid-phase chromatographic analysis method thereof | UNIV DALIAN TECH | 2013-10-16 | — | — | CN | claimed |
| CN-102276592-B | Related substance of olanzapine and preparation method and analytical method thereof | UNIV DALIAN TECH | 2013-10-16 | — | — | CN | claimed |
| CN-102276624-A | Olanzapine related substance and preparation method as well as high-efficiency liquid-phase chromatographic analysis method thereof | — | 2011-12-14 | — | — | CN | claimed |
| CN-102276592-A | Related substance of olanzapine and preparation method and analytical method thereof | — | 2011-12-14 | — | — | CN | claimed |
| CN-111991484-A | A pharmaceutical composition for treating respiratory diseases in winter | 天津中医药大学 | 2020-11-27 | — | — | CN | disclosed |
| US-10662185-B2 | Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-05-26 | — | — | US | disclosed |
| US-20190248783-A9 | AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-08-15 | — | — | US | disclosed |
| CN-109180765-A | A kind of pregnane type steroid alkaloid and its preparation method and application | 贵阳中医学院 | 2019-01-11 | — | — | CN | disclosed |
| CN-109172581-A | A kind of application of wild fan peanut alkaloids | 贵阳中医学院 | 2019-01-11 | — | — | CN | disclosed |
| CN-109134587-A | A kind of pregnane type steroid alkaloid and its preparation method and application | 贵阳中医学院 | 2019-01-04 | — | — | CN | disclosed |
| US-20180319794-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-08 | — | — | US | disclosed |
| US-7309790-B2 | Chemical compounds | PFIZER INC (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070185157-A1 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | disclosed |
| US-7217721-B2 | Tropane derivatives useful in therapy | PFIZER, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20050131011-A1 | Chemical compounds | PFIZER, INC. | 2005-06-16 | — | — | US | disclosed |
| US-20050107424-A1 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
| US-6855724-B2 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040014742-A1 | Antiinflammatory agents; viricides | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
| EP-0153803-A2 | Triazole antifungal agents | Pfizer Limited (GB) | 1985-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014742-A1 | Antiinflammatory agents; viricides | CCR5, CXCR1, CCR1 | TP53 3910/4885CYP2C19 1445/4885MEN1 4803/4885 |
| US-20190248783-A9 | AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE | AADAC, TNNI3, PAICS | TP53 4183/4885CYP2C19 289/4885MEN1 2194/4885 |
| US-10662185-B2 | Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use | AADAC, TNNI3, TNNT2 | TP53 4303/4885CYP2C19 56/4885MEN1 1870/4885 |
| US-20050107424-A1 | Tropane derivatives useful in therapy | CCR5, CXCR4, CX3CR1 | TP53 3451/4885CYP2C19 1272/4885MEN1 4667/4885 |
| US-20180319794-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE | AADAC, TNNI3, PAICS | TP53 4183/4885CYP2C19 289/4885MEN1 2194/4885 |
| US-20070185157-A1 | Tropane derivatives useful in therapy | CCR5, CXCR4, CX3CR1 | TP53 3451/4885CYP2C19 1272/4885MEN1 4667/4885 |
| US-20050131011-A1 | Chemical compounds | CCR5, CCR2, CX3CR1 | TP53 3061/4885CYP2C19 800/4885MEN1 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.