Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25326948 | 1.00 | RIPK1 (0.42) | RIPK1HRH3POLBP2RX7HSP90AA1 | |
| SCHEMBL25327484 | 0.94 | RIPK1 (0.42) | RIPK1HRH3 | |
| SCHEMBL25327480 | 0.94 | RIPK1 (0.42) | RIPK1HRH3 | |
| SCHEMBL25327730 | 0.86 | PRMT5 (0.41) | RIPK1HRH3POLBP2RX7HSP90AA1 | |
| SCHEMBL25327731 | 0.86 | PRMT5 (0.41) | RIPK1HRH3POLBP2RX7HSP90AA1 | |
| SCHEMBL25326219 | 0.83 | NR1H2 (0.47) | RIPK1 | |
| SCHEMBL25326222 | 0.83 | NR1H2 (0.47) | RIPK1 | |
| SCHEMBL25328455 | 0.81 | PRMT5 (0.40) | RIPK1HRH3PRMT5 | |
| SCHEMBL25328383 | 0.79 | POLB (0.50) | RIPK1POLBOPRM1OPRK1 | |
| SCHEMBL25328385 | 0.79 | POLB (0.50) | RIPK1POLBOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |