SCHEMBL253273

SCHEMBL253273

C=CCc1ccc2ccc3cccnc3c2n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.55
CCR1 P32246 5/20 0.55
MAPT P10636 4/20 0.55
CCR5 P51681 3/20 0.55
CCR8 P51685 3/20 0.55
KDM4E B2RXH2 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
MMP2 P08253 2/20 0.55
TSHR P16473 2/20 0.55
GMNN O75496 1/20 0.55
TP53 P04637 1/20 0.55
HSP90AA1 P07900 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
MMP9 P14780 1/20 0.55
ALOX15 P16050 1/20 0.55
NFKB1 P19838 1/20 0.55
MMP8 P22894 1/20 0.55
THPO P40225 1/20 0.55
MTOR P42345 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16681812 0.85 CCR1 (0.50) CCR1CCR5SMN1; SMN2TSHRTP53
SCHEMBL810237 0.83 CCR1 (0.55) LMNACCR1MAPTCCR5CCR8
SCHEMBL322128 0.81 LMNA (0.56) LMNACCR1MAPTCCR5CCR8
SCHEMBL167042 0.81 ALDH1A1 (0.47) LMNACCR1MAPTCCR5CCR8
SCHEMBL10012244 0.80 CCR1 (0.61) LMNACCR1MAPTCCR5CCR8
SCHEMBL6886445 0.80 CCR1 (0.52) LMNACCR1MAPTCCR5CCR8
Hydrochloric Acid SCHEMBL29113051 0.79 ALDH1A1 (0.46) LMNACCR1MAPTCCR5CCR8
Quinoline SCHEMBL11076491 0.77 ALDH1A1 (0.55) KDM4ESMN1; SMN2TP53CYP3A4HTT
SCHEMBL7555954 0.77 CCR1 (0.69) LMNACCR1MAPTCCR5CCR8
SCHEMBL30331100 0.77 CCR1 (0.61) LMNACCR1MAPTCCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180128767-A1 Small Volume In Vitro Analyte Sensor ABBOTT DIABETES CARE INC. (US) 2018-05-10 US disclosed
US-9891185-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2018-02-13 US disclosed
US-20170279146-A1 Biological Fuel Cell and Methods E. HELLER & COMPANY 2017-09-28 US disclosed
US-9662057-B2 Integrated sample acquisition and analyte measurement method ABBOTT DIABETES CARE INC. (US) 2017-05-30 US disclosed
US-9509010-B2 Biological fuel cell and methods ABBOTT DIABETES CARE INC. (US) 2016-11-29 US disclosed
US-20160334356-A1 Small Volume In Vitro Analyte Sensor THERASENSE, INC. 2016-11-17 US disclosed
US-20160235350-A1 Integrated Sample Acquisition and Analyte Measurement Device THERASENSE, INC. 2016-08-18 US disclosed
US-9341591-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-05-17 US disclosed
US-9316609-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-04-19 US disclosed
US-9291592-B2 Small volume in vitro analyte sensor ABBOTT DIABETES CARE INC. (US) 2016-03-22 US disclosed
US-6591125-B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator THERASENSE, INC. 2003-07-08 US disclosed
US-6531239-B2 Biological fuel cell and methods THERASENSE, INC. 2003-03-11 US disclosed
US-6461496-B1 BLOOD GLUCOSE THERASENSE, INC. 2002-10-08 US disclosed
US-20020025469-A1 Anions of equal number to cations to maintain charge neutrality, are disclosed. These spacer groups may be organic or inorganic in origin and may vary in length. The spacer groups may be saturated, containing single bonds, or may have THERASENSE, INC. 2002-02-28 US disclosed
US-6338790-B1 DETECTION OF BIOANALYTES IN A SMALL VOLUME SAMPLE; CONCENTRATION OF A BIOMOLECULE, SUCH AS GLUCOSE OR LACTATE, USING TECHNIQUES SUCH AS COULOMETRY, AMPEROMETRY, AND POTENTIOMETRY. AN ENZYME CAPABLE OF CATALYZING THE THERASENSE, INC. 2002-01-15 US disclosed
CN-1322254-A Small volume in vitro analytical sensor containing diffusible or non-leachable redox mediator THERASENSE INC (US) 2001-11-14 CN disclosed
US-6299757-B1 ANALYTICAL SENSORS FOR THE DETECTION OF BIOANALYTES; ESPECIALLY MONITORING GLUCOSE LEVELS IN DIABETIC PATIENTS THERASENSE, INC. 2001-10-09 US disclosed
US-6294281-B1 Biological fuel cell and method THERASENSE, INC. 2001-09-25 US disclosed
EP-1119637-A1 SMALL VOLUME $i(IN VITRO) ANALYTE SENSOR WITH DIFFUSIBLE OR NON-LEACHABLE REDOX MEDIATOR Therasense, Inc. (US) 2001-08-01 EP disclosed
WO-2000020626-A1 SMALL VOLUME IN VITRO ANALYTE SENSOR WITH DIFFUSIBLE OR NON-LEACHABLE REDOX MEDIATOR THERASENSE, INC. (US) 2000-04-13 WO disclosed