Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253304 | 1.00 | SIRT1 (0.46) | SIRT1SIRT6CTSSCTSKCA1 | |
| SCHEMBL23626318 | 0.94 | CTSK (0.49) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL25502552 | 0.88 | CTSK (0.45) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL22906234 | 0.88 | CTSK (0.46) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL10060514 | 0.88 | CTSK (0.43) | SIRT1SIRT6CTSSCTSKCA1 | |
| SCHEMBL16504607 | 0.87 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16504677 | 0.87 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16572281 | 0.87 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL10316221 | 0.87 | CTSK (0.46) | CTSSCTSKCA1CA2CAPN1 | |
| SCHEMBL16572287 | 0.87 | CTSS (0.48) | CTSSCTSKCA1CA2CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765019-B2 | Small-molecule-targeted protein degradation | BRANDEIS UNIVERSITY (US) | 2017-09-19 | — | — | US | disclosed |
| US-20130190340-A1 | Small-Molecule-Targeted Protein Degradation | BRANDEIS UNIVERSITY (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2588129-A2 | SMALL-MOLECULE-TARGETED PROTEIN DEGRADATION | Brandeis University (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003281-A2 | SMALL-MOLECULE-TARGETED PROTEIN DEGRADATION | BRANDEIS UNIVERSITY (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190340-A1 | Small-Molecule-Targeted Protein Degradation | SMURF2, SMURF1, MDM2 | SIRT1 3065/4885SIRT6 1484/4885CTSS 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.