Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410186 | 0.81 | MAPT (0.42) | RIPK1RIPK3MAPTMAPK14HPGD | |
| SCHEMBL2408774 | 0.81 | HPGD (0.41) | MAPTMAPK14HPGDSCN9A | |
| SCHEMBL2533237 | 0.78 | MKNK1 (0.36) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 | |
| SCHEMBL2408339 | 0.77 | RPS6KA3 (0.48) | RPS6KA3HPGDPIK3CAMTOR | |
| SCHEMBL2408398 | 0.77 | PTPN11 (0.41) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 | |
| SCHEMBL2409198 | 0.75 | HDAC6 (0.52) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 | |
| SCHEMBL2410524 | 0.75 | CFTR (0.47) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 | |
| SCHEMBL2408806 | 0.73 | CYP1A2 (0.44) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 | |
| SCHEMBL2408340 | 0.68 | FGFR1 (0.44) | RIPK1RIPK3RPS6KA3MAPTTP53 | |
| SCHEMBL2438823 | 0.68 | RPS6KA3 (0.39) | RIPK1RIPK3RPS6KA3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | claimed |