Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345301 | 0.87 | HPGD (0.41) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4832971 | 0.83 | KDM4E (0.37) | SLC6A2SLC6A4SLC6A3HTR1ADPP4 | |
| SCHEMBL1345258 | 0.81 | RARG (0.39) | ALDH1A1SLC6A2HTR1ADPP4TSHR | |
| SCHEMBL10965997 | 0.80 | KDM4E (0.35) | ALDH1A1MAPTKDM4E | |
| SCHEMBL8115982 | 0.79 | ALDH1A1 (0.40) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8125202 | 0.77 | ALDH1A1 (0.41) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8115681 | 0.77 | ALDH1A1 (0.38) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8131299 | 0.77 | SLC6A2 (0.41) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8129407 | 0.76 | ALDH1A1 (0.42) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8129015 | 0.76 | HTR1A (0.43) | ALDH1A1RHEBSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044035-B2 | Pharmaceutical compositions of pyrimidine-2,4,6-triones | UNIVERSITE DE LIEGE (BE) | 2011-10-25 | — | — | US | disclosed |
| US-20100261672-A1 | PHARMACEUTICAL COMPOSITIONS OF PYRIMIDINE-2,4,6-TRIONES | UNIVERSITE DE LIEGE (BE) | 2010-10-14 | — | — | US | disclosed |
| US-20070191404-A1 | Pharmaceutical compositions of pyrimidine-2,4,6-triones | HOFFMANN-LA ROCHE INC. | 2007-08-16 | — | — | US | disclosed |
| EP-1735007-A2 | CYCLODEXTRIN INCLUSION COMPLEXES OF PYRIMIDINE-2,4,6-TRIONES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097058-A2 | CYCLODEXTRIN INCLUSIONS COMPLEXES OF PYRIMIDINE-2,4,6-TRIONES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-20 | — | — | WO | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191404-A1 | Pharmaceutical compositions of pyrimidine-2,4,6-triones | TK1, TYMP, TYMS | ALDH1A1 3619/4885RHEB 3824/4885SLC6A2 3251/4885 |
| US-20100261672-A1 | PHARMACEUTICAL COMPOSITIONS OF PYRIMIDINE-2,4,6-TRIONES | TYMP, DPYD, TYMS | ALDH1A1 3179/4885RHEB 4776/4885SLC6A2 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.