Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.74 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | CNR2 | P34972 | 2/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.60 |
| ▸ | RXRA | P19793 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 4/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30141409 | 1.00 | GABRA1 (0.74) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL26608107 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL29519288 | 0.82 | TNKS (0.65) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL25337785 | 0.82 | TNKS (0.65) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL25337687 | 0.81 | GABRA1 (0.60) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL29518989 | 0.81 | GABRA1 (0.60) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL25938135 | 0.79 | GABRA1 (0.58) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL18313896 | 0.79 | GABRA1 (0.64) | GABRA1GABRB2ALOX5CNR2ACE2 | |
| SCHEMBL7699059 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2MEN1MAPTKMT2A | |
| SCHEMBL25197310 | 0.78 | GABRA1 (0.71) | GABRA1GABRB2ALOX5CNR2ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212509-B1 | METHOD FOR PREPARING WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, METHODS FOR PREPARING INTERMEDIATES OF WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, AND RELATED MONOHYDROXY PROTECTED INTERMEDIATE | BEIJING HONGHUI MEDITECH CO LTD (CN) | 2024-11-27 | — | — | EP | disclosed |
| US-20230339840-A1 | Preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates | BEIJING HONGHUI MEDITECH CO., LTD (CN) | 2023-10-26 | — | — | US | disclosed |
| US-20230339840-A1 | Preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates | BEIJING HONGHUI MEDITECH CO., LTD (CN) | 2023-10-26 | — | — | US | disclosed |
| EP-4212509-A1 | METHOD FOR PREPARING WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, METHODS FOR PREPARING INTERMEDIATES OF WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, AND RELATED MONOHYDROXY PROTECTED INTERMEDIATE | Beijing Honghui Meditech Co., Ltd (CN) | 2023-07-19 | — | — | EP | disclosed |
| CN-112125805-B | Water-soluble magnolol derivative, preparation method of honokiol derivative and intermediate thereof, and related monohydroxy protected intermediate | 北京红惠新医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| WO-2022052683-A1 | METHOD FOR PREPARING WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, METHODS FOR PREPARING INTERMEDIATES OF WATER-SOLUBLE MAGNOLOL DERIVATIVE AND HONOKIOL DERIVATIVE, AND RELATED MONOHYDROXY PROTECTED INTERMEDIATE | 北京红惠新医药科技有限公司 | 2022-03-17 | — | — | WO | disclosed |
| CN-112125805-A | Water-soluble magnolol derivative, preparation method of honokiol derivative and intermediate thereof, and related monohydroxy protected intermediate | 北京红惠新医药科技有限公司 | 2020-12-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339840-A1 | Preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates | MSMO1, HSD11B1, HMOX1 | GABRA1 2200/4885GABRB2 1278/4885ALOX5 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.