Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12538032 | 0.86 | TSHR (0.31) | TSHRCTDSP1BBOX1 | |
| SCHEMBL7136765 | 0.84 | CA1 (0.33) | TSHRCTDSP1 | |
| SCHEMBL11732406 | 0.71 | LMNA (0.33) | TSHRCTDSP1LMNAAPOBEC3AAPOBEC3G | |
| SCHEMBL641601 | 0.71 | TSHR (0.32) | TSHRCTDSP1 | |
| SCHEMBL17102835 | 0.69 | — | — | |
| Acetic Acid SCHEMBL21384672 | 0.67 | CA1 (0.47) | TSHRCTDSP1LMNAAPOBEC3AAPOBEC3G | |
| Acetic Acid SCHEMBL21382614 | 0.67 | CA1 (0.47) | TSHRCTDSP1LMNAAPOBEC3AAPOBEC3G | |
| Cyclohexane SCHEMBL1163673 | 0.67 | LMNA (0.67) | TSHRLMNA | |
| Cyclohexane SCHEMBL15266693 | 0.67 | LMNA (0.67) | TSHRLMNA | |
| Cyclopentane SCHEMBL8144947 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044136-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | LILLY CO ELI (US) | 2017-02-16 | — | — | US | disclosed |
| US-20150376178-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | ELI LILLY AND COMPANY | 2015-12-31 | — | — | US | disclosed |
| US-8748459-B2 | Pyridinoylpiperidines as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120329820-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | ELI LILLY AND COMPANY (US) | 2012-12-27 | — | — | US | disclosed |
| US-8044207-B2 | Pyridinoylpiperidines as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2011-10-25 | — | — | US | disclosed |
| US-20090209563-A1 | Pyridinoylpiperidines as 5-HT1F agonists | ELI LILLY AND COMPANY | 2009-08-20 | — | — | US | disclosed |
| US-20080300407-A1 | Pyridinoylpiperidines as 5-HT1F agonists | ELI LILLY AND COMPANY (IN) | 2008-12-04 | — | — | US | disclosed |
| US-7423050-B2 | Pyridinoylpiperidines as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2008-09-09 | — | — | US | disclosed |
| EP-1492786-B1 | PYRIDINOYLPIPERIDINES AS 5-HT1F AGONISTS | LILLY CO ELI (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20050222206-A1 | Pyridinoylpiperidines as 5-ht1f agonists | ELI LILLY AND COMPANY | 2005-10-06 | — | — | US | disclosed |
| EP-1492786-A1 | PYRIDINOYLPIPERIDINES AS 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003084949-A1 | PYRIDINOYLPIPERIDINES AS 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300407-A1 | Pyridinoylpiperidines as 5-HT1F agonists | HTR1F, HTR1A, HTR1E | TSHR 506/4885CTDSP1 2922/4885LMNA 1866/4885 |
| US-20120329820-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | HTR1F, HTR1A, HTR1E | TSHR 494/4885CTDSP1 2779/4885LMNA 1767/4885 |
| US-20170044136-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | HTR1F, HTR1A, HTR1E | TSHR 494/4885CTDSP1 2779/4885LMNA 1767/4885 |
| US-20050222206-A1 | Pyridinoylpiperidines as 5-ht1f agonists | HTR1F, HTR1A, HTR1E | TSHR 494/4885CTDSP1 2779/4885LMNA 1767/4885 |
| US-20150376178-A1 | Pyridinoylpiperidines As 5-HT1F Agonists | HTR1F, HTR1A, HTR1E | TSHR 494/4885CTDSP1 2779/4885LMNA 1767/4885 |
| US-20090209563-A1 | Pyridinoylpiperidines as 5-HT1F agonists | HTR1F, HTR1A, HTR1E | TSHR 494/4885CTDSP1 2779/4885LMNA 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.