Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25344845 | 0.89 | ALDH1A1 (0.46) | MEN1KMT2AMAPTGAAABL1 | |
| SCHEMBL25342692 | 0.88 | MAPT (0.38) | MEN1KMT2AMAPTGAAABL1 | |
| SCHEMBL25346033 | 0.84 | MEN1 (0.52) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL31376654 | 0.84 | CHRM2 (0.41) | MEN1KMT2AMAPTGAAABL1 | |
| SCHEMBL25343192 | 0.83 | AAK1 (0.39) | L3MBTL1METAP2MTNR1AMTNR1B | |
| SCHEMBL25344251 | 0.78 | METAP2 (0.36) | MAPTGAAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL25345810 | 0.76 | METAP2 (0.36) | MAPTSMN1; SMN2METAP2 | |
| SCHEMBL25346494 | 0.76 | METAP2 (0.36) | MAPTALDH1A1SMN1; SMN2METAP2 | |
| SCHEMBL5028697 | 0.76 | MAPT (0.44) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL25343983 | 0.74 | KAT2B (0.56) | MAPTALDH1A1TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |