Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342692 | 0.89 | MAPT (0.38) | ALDH1A1MAPTL3MBTL1TDP1GAA | |
| SCHEMBL25344735 | 0.89 | MEN1 (0.39) | ALDH1A1MAPTL3MBTL1TDP1GAA | |
| SCHEMBL31376654 | 0.84 | CHRM2 (0.41) | ALDH1A1MAPTTDP1GAASMN1; SMN2 | |
| SCHEMBL25343983 | 0.81 | KAT2B (0.56) | ALDH1A1MAPTTDP1SMN1; SMN2METAP2 | |
| SCHEMBL25344251 | 0.79 | METAP2 (0.36) | ALDH1A1MAPTGAASMN1; SMN2METAP2 | |
| SCHEMBL25346494 | 0.77 | METAP2 (0.36) | ALDH1A1MAPTSMN1; SMN2METAP2HPGD | |
| SCHEMBL25345810 | 0.77 | METAP2 (0.36) | MAPTSMN1; SMN2METAP2KDM4ECHRM2 | |
| SCHEMBL5028697 | 0.76 | MAPT (0.44) | ALDH1A1MAPTL3MBTL1TDP1GAA | |
| SCHEMBL25346033 | 0.74 | MEN1 (0.52) | ALDH1A1MAPTSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL25343679 | 0.74 | ALDH1A1 (0.60) | ALDH1A1MAPTL3MBTL1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |