Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Mebufotenin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B known ✓ | P41595 | 4/20 | 0.68 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.68 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.68 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.68 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.67 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.59 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 6/20 | 0.68 |
| ▸ | HTR1B | P28222 | 6/20 | 0.68 |
| ▸ | HTR7 | P34969 | 4/20 | 0.68 |
| ▸ | HTR6 | P50406 | 4/20 | 0.68 |
| ▸ | HTR5A | P47898 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.68 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mebufotenin SCHEMBL30777166 | 0.89 | HTR2A (0.75) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| Mebufotenin SCHEMBL25418408 | 0.89 | HTR2A (0.75) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| Mebufotenin SCHEMBL30199593 | 0.89 | KMT2A (0.84) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| Mebufotenin SCHEMBL23927938 | 0.89 | KMT2A (0.84) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| 5-Methoxytryptamine SCHEMBL30933118 | 0.84 | HTR1A (0.78) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| 5-Methoxytryptamine SCHEMBL31240192 | 0.84 | HTR1A (0.78) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| 5-Methoxytryptamine SCHEMBL7094587 | 0.84 | HTR1A (0.78) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| 5-Methoxytryptamine SCHEMBL7094589 | 0.84 | HTR1A (0.78) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| 5-Methoxytryptamine SCHEMBL30960099 | 0.83 | HTR1A (0.76) | HTR1AHTR1BHTR2BHTR2AHTR2C | |
| Mebufotenin SCHEMBL25184829 | 0.82 | HTR2A (0.67) | HTR1AHTR1BHTR2BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250059-A1 | SYNTHESIS OF N,N-DIMETHYLTRYPTAMINE-TYPE COMPOUNDS, METHODS, AND USES | SMALL PHARMA LTD (GB) | 2023-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250059-A1 | SYNTHESIS OF N,N-DIMETHYLTRYPTAMINE-TYPE COMPOUNDS, METHODS, AND USES | TPH2, TPH1, HTR2C | HTR2B 17/4885HTR2A 9/4885HTR2C 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.