Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27159103 | 0.87 | FKBP1A (0.33) | FKBP1AMIF | |
| SCHEMBL1974403 | 0.84 | MMP2 (0.36) | NR1D1FKBP1A | |
| SCHEMBL752424 | 0.82 | MAPK1 (0.36) | — | |
| SCHEMBL27158567 | 0.81 | FKBP1A (0.32) | NR1D1FKBP1A | |
| SCHEMBL22648657 | 0.79 | MMP2 (0.41) | — | |
| SCHEMBL201027 | 0.79 | MMP2 (0.41) | — | |
| SCHEMBL27158695 | 0.76 | FKBP1A (0.34) | FKBP1AMIF | |
| SCHEMBL22654848 | 0.76 | FKBP1A (0.37) | FKBP1A | |
| SCHEMBL7547847 | 0.75 | FKBP1A (0.46) | FKBP1A | |
| SCHEMBL4942063 | 0.72 | ACE (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134717-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| EP-2662095-A1 | Pyrrolobenzodiazepines and conjugates thereof | Spirogen Sàrl (CH) | 2013-11-13 | — | — | EP | disclosed |
| EP-2528625-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN SARL (CH) | 2013-07-10 | — | — | EP | disclosed |
| US-20130028917-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN DEVELOPMENTS SÀRL (CH) | 2013-01-31 | — | — | US | disclosed |
| US-20110256157-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110256157-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | HDAC10, PBDC1, PDCD10 | NR1D1 182/4885FKBP1A 1020/4885MIF 3860/4885 |
| US-20180134717-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | HDAC10, PBDC1, PDCD10 | NR1D1 182/4885FKBP1A 1020/4885MIF 3860/4885 |
| US-20130028917-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | HDAC10, PBDC1, PDCD10 | NR1D1 182/4885FKBP1A 1020/4885MIF 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.