Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25356477 | 0.85 | MGMT (0.41) | MGMTHTTALDH1A1LMNAPOLB | |
| SCHEMBL16738992 | 0.79 | MGMT (0.50) | MGMTHTTLMNAMEN1KMT2A | |
| SCHEMBL6882078 | 0.77 | HPD (0.39) | MGMTHTTALDH1A1LMNAPOLB | |
| SCHEMBL5810886 | 0.75 | NPC1 (0.41) | ALDH1A1LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL1559732 | 0.75 | MAPT (0.43) | MGMTHTTALDH1A1LMNAPOLB | |
| SCHEMBL31190976 | 0.75 | MAOB (0.47) | MGMTHTTALDH1A1LMNAPOLB | |
| SCHEMBL26022683 | 0.75 | MAOB (0.47) | MGMTHTTALDH1A1LMNAPOLB | |
| SCHEMBL6888812 | 0.72 | HTR1A (0.42) | MGMTALDH1A1LMNAPOLBMEN1 | |
| SCHEMBL1708309 | 0.72 | MGMT (0.53) | MGMTMEN1KMT2AMAPTCYP19A1 | |
| SCHEMBL8564287 | 0.69 | MGMT (0.61) | MGMTHTTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4475837-A2 | TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF | Adarx Pharmaceuticals, Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154896-A2 | TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF | ADARX PHARMACEUTICALS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |