⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083049 | 0.86 | CA2 (0.38) | — | |
| SCHEMBL30598789 | 0.86 | CA2 (0.38) | — | |
| SCHEMBL2907407 | 0.84 | CA2 (0.37) | — | |
| SCHEMBL21385233 | 0.84 | CHRNB2 (0.39) | — | |
| SCHEMBL30994809 | 0.84 | CHRNB2 (0.39) | — | |
| Water SCHEMBL23356455 | 0.84 | CA2 (0.37) | — | |
| Hydrochloric Acid SCHEMBL27687817 | 0.84 | CA2 (0.37) | — | |
| Hydrochloric Acid SCHEMBL28060532 | 0.84 | CA2 (0.37) | — | |
| SCHEMBL4447517 | 0.80 | ALDH1A1 (0.35) | — | |
| SCHEMBL16057898 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101001642-A | Combination therapy for diabetes, obesity and cardiovascular disease using GDF-8 inhibitors | WYETH CORP (US) | 2007-07-18 | — | — | CN | claimed |
| CN-105769955-A | Composition comprising ginseng extracts with enhanced ginsenoside contents | 株式会社爱茉莉太平洋 | 2016-07-20 | — | — | CN | disclosed |
| EP-1881976-B1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20120070413-A1 | METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES | KIM TAE-SEONG (US) | 2012-03-22 | — | — | US | disclosed |
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110118252-A1 | SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-7858623-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2010-12-28 | — | — | US | disclosed |
| CN-101152728-B | Fiber board capable of capturing and decomposing aldehyde | NICHIHA KK | 2010-12-01 | — | — | CN | disclosed |
| CN-100575066-C | Functional construction board | NICHIHA KK | 2009-12-30 | — | — | CN | disclosed |
| US-20080312232-A1 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2008-12-18 | — | — | US | disclosed |
| CN-101248059-A | Substituted amide derivatives as protein kinase inhibitors | AMGEN INC (US) | 2008-08-20 | — | — | CN | disclosed |
| CN-101235668-A | Functional construction board | NICHIHA KK (JP) | 2008-08-06 | — | — | CN | disclosed |
| CN-101171263-A | Method for humanizing immunoglobulin variable regions by rational modification of complementarity determining region residues | BIOGEN IDEC INC (US) | 2008-04-30 | — | — | CN | disclosed |
| CN-101152728-A | Fiber board capable of capturing and decomposing aldehyde | NICHIHA KK (JP) | 2008-04-02 | — | — | CN | disclosed |
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| CN-101001642-A | Combination therapy for diabetes, obesity and cardiovascular disease using GDF-8 inhibitors | WYETH CORP (US) | 2007-07-18 | — | — | CN | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| CN-1119345-C | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors | SCHERING CORP (US) | 2003-08-27 | — | — | CN | disclosed |
| CN-1314906-A | Salts of paroxetine | SMITHKLINE BEECHAM PLC (GB) | 2001-09-26 | — | — | CN | disclosed |
| CN-1267302-A | Benzo (5.6) cycloheptopyridine compounds useful as farnesyl protein transferase inhibitors | SCHERING CORP (US) | 2000-09-20 | — | — | CN | disclosed |